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KMID : 0616120220530010001
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Korean Journal of Pharmacognosy
2022 Volume.53 No. 1 p.1 ~ p.7
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Neuroprotective Activity of Luteolin Isolated from Lonicera japonica
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Kim Eun-Seo
Ma Choong-Je
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Abstract
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In the previous study, we reported that luteolin isolated from Lonicera japonica methanolic extract had potent neuroprotective activities in neuronal cell death injured by excessive glutamate. In this study, we tried to confirm the neuroprotective activities of luteolin in glutamate injured HT22 cells and establish mechanisms of neuroprotective action of luteolin. We used HT22 cell death injured by glutamate as a bioassay system. Luteolin decreased reactive oxygen species increased by excessive glutamate treatment in HT22 cells. Also, Ca2+ concentration was decreased by luteolin treatment. Luteolin made mitochondrial membrane potential maintain to normal condition. It also increased not only glutathione reductase but also peroxidase to the control level. And it increased amount of glutathione, an endogenous antioxidant. These results suggested that luteolin isolated from L. japonica showed potent neuroprotective activity through the anti-oxidative pathway.
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KEYWORD
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Lonicera japonica, Luteolin, Neuroprotection, Antioxidant, Alzheimer’s disease
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